toxic epidermal necrolysis

GC: n

S: Medscape – (last access: 23 March 2018); WebMD – (last access: 23 March 2018).

N: 1. – toxic (adj): 1660s, from French toxique and directly from Late Latin toxicus “poisoned,” from Latin toxicum “poison,” from Greek toxikon (pharmakon) “(poison) for use on arrows,” from toxikon, neuter of toxikos “pertaining to arrows or archery,” and thus to a bow, from toxon “bow,” probably from a Scythian word that also was borrowed into Latin as taxus “yew.” Watkins suggests a possible source in Iranian taxša- “bow,” from PIE *tekw- “to run, flee.” As a noun from 1890.
– epidermal (adj): From the noun epidermis (1620s, from Late Latin epidermis, from Greek epidermis “the outer skin,” from epi “on” + derma “skin” (from PIE root *der- “to split, flay, peel,” with derivatives referring to skin and leather). Related: Epidermal; epidermic.
– necrolysis (n): From necro- + Greek lysis, loosening. Necrosis and loosening of tissue.
Abbr. TEN
2. A syndrome in which a large portion of the skin becomes intensely red and peels off in the manner of a second-degree burn; it is often accompanied by blisters.
3. Toxic epidermal necrolysis (TEN), occurs in adults, often secondary to drugs (e.g., zdrugdatabasez ampicillin, allopurinol) and occasionally to Staphylococcus infections in an immunosuppressed patient. TEN is a reaction to a variety of antigenic materials that cause a suprabasilar split in the epidermis with necrosis of much of the overlying epidermis.
4. The staphylococcal scalded skin syndrome usually occurs in children less than 5 years old, whereas drug-induced toxic epidermal necrolysis is considered a disease of adults. Except for the age differential, the two often cannot be distinguished clinically. Therefore, rapid and definitive biopsy diagnosis is essential in the management of patients with acute exfoliative skin disorders. We wish to report the case of a young child with proven toxic epidermal necrolysis and review the manifestations of this disease, as well as the staphylococcal scalded skin syndrome.

S: 1. OED – (last access: 23 March 2018); Farlex Partner Medical Dictionary © Farlex 2012 – (last access: 26 March 2018). 2. (last access: 23 March 2018). 3. TERMIUM PLUS – (last access: 23 March 2018). 4. (last access: 23 March 2018).

SYN: 1. nonstaphylococcal scalded skin syndrome. 2. toxic epidermal necrolysis, Lyell’s disease, Lyell’s syndrome scalded skin syndrome, toxic bullous epidermolysis. (context)

S: 1. COSNAUTAS/LIBRO ROJO (last access: 23 March 2018). 2. GDT – (last access: 26 March 2018).

CR: staphylococcal scalded skin syndrome, biopsy